DOSERANKEVIDENCE-BASED SUPPLEMENTS
DOSERANKEVIDENCE-BASED SUPPLEMENTS© 2026 DoseRank · Evidence-based supplements
Methodology·Outcomes·Categories
DOSERANKEVIDENCE-BASED SUPPLEMENTS
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  3. ·Liver function
  4. ·Liver function

Improve liver function

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What this outcome means

Liver function reflects how well your liver handles its daily jobs of filtering, processing nutrients, and clearing waste from the blood. On DoseRank it maps to a defined health outcome built from human studies on liver enzyme levels like ALT and AST, bilirubin, and other markers of hepatic performance – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Watching liver panelsPeople monitoring enzyme results flagged on routine blood work.
Metabolic loadThose carrying extra weight or fat stored around the liver.
Higher daily exposureAdults whose alcohol, diet, or medication habits tax the liver.
Stack buildersAlready taking supplements such as N-Acetyl-L-Cysteine (NAC) or Silymarin and want the dose right.

Evidence level

92Strong

N-Acetyl-L-Cysteine (NAC) and Silymarin – have strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 77 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

N-Acetyl-L-Cysteine (NAC) and Silymarin are the best supported ingredient signals for this outcome.

Dose matchedDoseFit 77

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: N-Acetyl-L-Cysteine (NAC) 800 mg vs 600-1200 mg, Silymarin 300 mg vs 140-420 mg.

ProcessedProcessedEvery product DoseRank ingested and scored for this outcome, before any availability or relevance filtering.
2.8k
AvailableAvailableOf the products processed, how many are currently in stock and purchasable from a tracked retailer.
2.8k
IngredientsIngredientsNumber of relevant ingredients for this outcome. Each is judged on its own evidence and dose fit score.
18
BrandsBrandsNumber of unique brands represented across the ranked products for this outcome.
331
CoverageCoverageHigher is betterShare of the relevant, in-stock market DoseRank has structured data for. Higher coverage means fewer blind spots in the ranking.
100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.
CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better
ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better
EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better
ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better
TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better
PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Relevant ingredients

Which ingredient types matter for liver functionOpen to see which ingredient types matter for liver function

1.7k products across 5 ingredient types — open to filter the ranking.
Use types to filter ranked products

Botanicals/Herbal Extracts

882 products

Concentrated plant and herbal extracts standardized to actives. Potency depends on the extract ratio and marker content, not raw weight.

Typical: ,

Amino Acids & Derivatives

458 products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical: ,

Antioxidants & Bioactive Compounds

41 products

Molecules that neutralize free radicals and tune cell signaling. Helpful in balance; mega-doses can blunt the body's own adaptive defenses.

Typical: ,

Vitamins

185 products

Essential micronutrients the body can't make in sufficient amounts. Fat-soluble ones (A, D, E, K) store up; water-soluble ones need regular topping-up.

Typical:

Fatty Acids & Lipids

168 products

Dietary fats including omega-3s and structural lipids. Look at the active EPA/DHA amounts and freshness, since oils oxidize and turn rancid.

Typical: ,

Top decision cards

Best products for liver function

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for liver function

#1

MRM Nutrition, Liver X®, 60 Vegan Capsules

MRM Nutrition$0.66 / serving4.7 · 563Available now

Why this ranks here

  • Evidence fitN-Acetyl-L-Cysteine (NAC) and Silymarin are the strongest evidence signals for this outcome.
  • Dose fit2 of 2 dosed ingredients land in the studied range. N-Acetyl-L-Cysteine (NAC) at 800 mg lands inside the studied 600-1200 mg window.
  • Price / serving$0.66 per serving — high price tier for this outcome.
  • AvailabilityIn stock across major retailers; 99% availability confidence.
  • TrustMixed trust signals — ratings are positive but the base is limited.

Trade-offs

Popularity trails the other picks hereValue for money trails the rest of this list

The numbers

87
96
77
44

800 mgIn rangeinside the studied 600-1200 mg window
300 mgIn rangeinside the studied 140-420 mg window
Compare top 3Product dataOpen at retailer

The rest of the ranking · DoseRank

Top 10 ranked products
#ProductPrice

Keep exploring

Related outcomes

Alanine aminotransferase (ALT)Liver enzyme used to assess hepatocellular injury.Alkaline phosphataseEnzyme related to bile ducts, bone, and liver.Aspartate aminotransferase (AST)Enzyme used to assess liver and muscle injury.Gamma-glutamyl transferase (GGT)Marker of cholestasis, alcohol exposure, or hepatic stress.
Last updated Jun 12, 2026

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Comparison preview

Compare the top 3, side by side

Sign-in to see all metrics

The top three for the current view — free to read, no account. Saving, exporting, alerts and the full filter set unlock once you sign in or build a personal report.

Metric
#1MRM Nutrition, Liver X®, 60 Vegan CapsulesMRM Nutrition · $0.66/serving
#2NOW Foods, NAC, 1,000 mg, 120 TabletsNOW Foods · $0.16/serving
#3NOW Foods, NAC, 600 mg, 250 CapsulesNOW Foods · $0.10/serving
Composite878685
Clinical968987
Dose fit778267
Value447785
Popularity499999
Key dosages & price · raw values
800 mg1000 mgHighest600 mg
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