Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

Lower AST

What this outcome means

Aspartate aminotransferase, or AST, is an enzyme that leaks into the blood when liver or muscle cells are stressed, so the level hints at how those tissues are holding up. On DoseRank it maps to a defined health outcome built from human studies on serum AST levels, the AST-to-ALT ratio, and liver enzyme trends – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Elevated liver enzymesBlood tests flagging AST above the normal reference range.

Fatty liver concernsPeople watching liver markers tied to metabolic strain.

Heavy training loadsAthletes whose intense muscle work can lift enzyme readings.

Stack buildersAlready taking supplements such as Silymarin and want the dose right.

Evidence level

88Strong

Silymarin – has strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 86 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

Silymarin is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 86

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Silymarin 600 mg vs 140-700 mg.

Processed

491

Available

491

Ingredients

Brands

122

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Lower AST

What this outcome means

Who it's for

Elevated liver enzymesBlood tests flagging AST above the normal reference range.

Fatty liver concernsPeople watching liver markers tied to metabolic strain.

Heavy training loadsAthletes whose intense muscle work can lift enzyme readings.

Stack buildersAlready taking supplements such as Silymarin and want the dose right.

Evidence level

88Strong

Best ingredients

Silymarin is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 86

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Silymarin 600 mg vs 140-700 mg.

Processed

491

Available

491

Ingredients

Brands

122

Coverage

100%

Relevant ingredients

Which ingredient types matter for aspartate aminotransferase (ast)Open to see which ingredient types matter for aspartate aminotransferase (ast)

378 products across 1 ingredient types — open to filter the ranking.

Use types to filter ranked products

Botanicals/Herbal Extracts

378 products

Concentrated plant and herbal extracts standardized to actives. Potency depends on the extract ratio and marker content, not raw weight.

Typical: , ,

Top decision cards

Best products for aspartate aminotransferase (ast)

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for aspartate aminotransferase (ast)

NOW Foods, Milk Thistle Extract, 750 mg, 90 Veg Capsules

NOW Foods$0.23 / serving4.8 · 4,153Available now

Also helps with

Alanine aminotransferase (ALT)

Hepatotoxicity or liver injury

Liver function

Why this ranks here

Evidence fitSilymarin is the strongest evidence signal for this outcome.
Dose fitSilymarin at 600 mg lands inside the studied 140-700 mg window.
Price / serving$0.23 per serving — mid price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

600 mgIn rangeinside the studied 140-700 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

NOW Foods, Milk Thistle Extract, 300 mg, 200 Veg Capsules

NOW FoodsClinical87Dose fit71Popularity98$0.12/ serving

NOW Foods, Milk Thistle Extract, 100 Veg Capsules

NOW FoodsClinical87Dose fit71Popularity90$0.16/ serving

NOW Foods, Milk Thistle Extract, 450 mg, 120 Softgels

NOW FoodsClinical87Dose fit76Popularity81$0.20/ serving

NOW Foods, Milk Thistle Extract with Turmeric, 120 Veg Capsules

NOW FoodsClinical87Dose fit71Popularity90$0.21/ serving

California Gold Nutrition, Milk Thistle Plus with Turmeric Extract and Artichoke Extract, 120 Veggie Capsules

California Gold NutritionClinical86Dose fit67Popularity81$0.12/ serving

NOW Foods, Liver Refresh™, 180 Veg Capsules

NOW FoodsClinical87Dose fit71Popularity90$0.40/ serving

Solgar, Milk Thistle, 250 Vegetable Capsules (450 mg per Capsule)

SolgarClinical87Dose fit76Popularity45$0.14/ serving

Solgar, Milk Thistle, 100 Vegetable Capsules (450 mg per Capsule)

SolgarClinical87Dose fit76Popularity45$0.17/ serving

Nature's Way, Thisilyn®, Milk Thistle Extract, 100 Vegan Capsules (175 mg per Capsule)

Nature's WayClinical86Dose fit67Popularity77$0.27/ serving