DOSERANKEVIDENCE-BASED SUPPLEMENTS
DOSERANKEVIDENCE-BASED SUPPLEMENTS© 2026 DoseRank · Evidence-based supplements
Methodology·Outcomes·Categories
DOSERANKEVIDENCE-BASED SUPPLEMENTS
Stack
  1. Search
  2. ·Outcomes
  3. ·Liver function
  4. ·Gamma-glutamyl transferase (GGT)

Lower GGT

View top productsTake the 60-sec quizGet the reportSee methodology

What this outcome means

Gamma-glutamyl transferase is a liver enzyme whose level in your blood reflects bile-duct health and stress on the liver, including from alcohol. On DoseRank it maps to a defined health outcome built from human studies on serum GGT levels, liver enzyme panels, and cholestasis markers – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Elevated liver enzymesA blood test flagging raised GGT for follow-up.
Alcohol-aware trackingPeople watching how drinking habits register in liver markers.
Bile-flow concernsSigns of cholestasis or blocked bile prompting closer checks.
Stack buildersAlready taking supplements such as Silybin Phytosome and want the dose right.

Evidence level

77Moderate-strong

Silybin Phytosome – has moderate public evidence for this outcome. This usually means there are smaller or mechanistic studies, but not randomized human trials. A DoseFit Score of 78 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best available ingredients

Silybin Phytosome is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 78

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Silybin Phytosome 320 mg vs 160-480 mg.

ProcessedProcessedEvery product DoseRank ingested and scored for this outcome, before any availability or relevance filtering.
15
AvailableAvailableOf the products processed, how many are currently in stock and purchasable from a tracked retailer.
15
IngredientsIngredientsNumber of relevant ingredients for this outcome. Each is judged on its own evidence and dose fit score.
1
BrandsBrandsNumber of unique brands represented across the ranked products for this outcome.
8
CoverageCoverageHigher is betterShare of the relevant, in-stock market DoseRank has structured data for. Higher coverage means fewer blind spots in the ranking.
100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.
CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better
ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better
EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better
ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better
TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better
PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

Not sure which is right for you?

Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.

Take 60-sec quiz

Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Relevant ingredients

Which ingredient types matter for gamma-glutamyl transferase (ggt)Open to see which ingredient types matter for gamma-glutamyl transferase (ggt)

15 products across 1 ingredient types — open to filter the ranking.
Use types to filter ranked products

Botanicals/Herbal Extracts

15 products

Concentrated plant and herbal extracts standardized to actives. Potency depends on the extract ratio and marker content, not raw weight.

Typical:

Top decision cards

Best products for gamma-glutamyl transferase (ggt)

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for gamma-glutamyl transferase (ggt)

#1

Natural Factors, Herbal Factors®, Premium Milk Thistle, 160 mg, 60 Vegetarian Capsules

Natural Factors$0.27 / serving4.7 · 1,426Available now

Why this ranks here

  • Evidence fitSilybin Phytosome has moderate human evidence for this outcome.
  • Dose fitSilybin Phytosome at 320 mg lands inside the studied 160-480 mg window.
  • Price / serving$0.27 per serving — mid price tier for this outcome.
  • AvailabilityIn stock across major retailers; 99% availability confidence.
  • TrustSolid trust signals from buyer ratings, with room to grow.

Trade-offs

Evidence depth trails the rest of this list

The numbers

84
89
78
68

320 mgIn rangeinside the studied 160-480 mg window
Compare top 3Product dataOpen at retailer

The rest of the ranking · DoseRank

Top 10 ranked products
#ProductPrice

Keep exploring

Related outcomes

Alanine aminotransferase (ALT)Liver enzyme used to assess hepatocellular injury.Alkaline phosphataseEnzyme related to bile ducts, bone, and liver.Aspartate aminotransferase (AST)Enzyme used to assess liver and muscle injury.Liver functionOverall biochemical or clinical hepatic performance.
Last updated Jun 12, 2026

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Comparison preview

Compare the top 3, side by side

Sign-in to see all metrics

The top three for the current view — free to read, no account. Saving, exporting, alerts and the full filter set unlock once you sign in or build a personal report.

Metric
#1Natural Factors, Herbal Factors®, Premium Milk Thistle, 160 mg, 60 Vegetarian CapsulesNatural Factors · $0.27/serving
#2Life Extension, Advanced Milk Thistle, 60 SoftgelsLife Extension · $0.63/serving
#3Thorne, Milk Thistle Phytosome, 90 Capsules (180 mg per Capsule)Thorne · $0.48/serving
Composite848382
Clinical898987
Dose fit789268
Value684854
Popularity838991
Key dosages & price · raw values
320 mg920 mgHighest180 mg
Rating
Number of ratings
Price
Price per serving
Serving size
Trust

See more metrics for every product.

Free with an account. No card required.
Unlocks with accountFull list of ingredients and dosagesFull list of metricsPrice-drop alertsRanking-changes alertsPersistent stack