Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

DOSERANKEVIDENCE-BASED SUPPLEMENTS

Normalize alkaline phosphatase

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See methodology

What this outcome means

Alkaline phosphatase is an enzyme measured in your bloodwork that ties to your bile ducts, bones, and liver, so shifts can point in several directions. On DoseRank it maps to a defined health outcome built from human studies on serum alkaline phosphatase levels, bile-duct markers, and bone turnover indicators – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Abnormal liver panelBloodwork flagging alkaline phosphatase outside the usual range.

Bile flow concernsSigns of pressure or blockage along the bile ducts.

Bone turnover watchersPeople tracking the enzyme as a window into bone activity.

Stack buildersAlready taking supplements such as TUDCA and want the dose right.

Evidence level

92Strong

TUDCA – has strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 67 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

TUDCA is the best supported ingredient signal for this outcome.

Dose partly matchedDoseFit 67

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: TUDCA 500 mg vs 500-1500 mg.

Processed

18

Available

18

Ingredients

1

Brands

14

Coverage

100%

Relevant ingredients

Which ingredient types matter for alkaline phosphataseOpen to see which ingredient types matter for alkaline phosphatase

16 products across 1 ingredient types — open to filter the ranking.

Use types to filter ranked products

Antioxidants & Bioactive Compounds

16 products

Molecules that neutralize free radicals and tune cell signaling. Helpful in balance; mega-doses can blunt the body's own adaptive defenses.

Typical:

Top decision cards

Best products for alkaline phosphatase

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for alkaline phosphatase

#1

Nutricost, TUDCA, 500 mg, 30 Capsules

Nutricost$0.90 / serving4.8 · 2,244Available now

Also helps with

Cholestasis

Alanine aminotransferase (ALT)

Hepatic steatosis

Why this ranks here

Evidence fitTUDCA is the strongest evidence signal for this outcome.
Dose fitTUDCA at 500 mg lands inside the studied 500-1500 mg window.
Price / serving$0.90 per serving — high price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

83

89

67

50

500 mgIn rangeinside the studied 500-1500 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

2

Nutricost, TUDCA, Unflavored, 0.9 oz (25 g)

NutricostClinical89Dose fit67Popularity68$0.72/ serving

3

Primaforce, TUDCA, 500 mg, 30 Capsules

PrimaforceClinical89Dose fit67Popularity76$0.73/ serving

4

Nature's Craft, TUDCA, 60 Capsules (250 mg per Capsule)

Nature's CraftClinical89Dose fit67Popularity68$0.87/ serving

5

BodyBio, TUDCA, 60 Capsules (250 mg per Capsule)

BodyBioClinical89Dose fit67Popularity91$1.80/ serving

6

ProHealth Longevity, TUDCA, 60 Capsules (250 mg per Capsule)

ProHealth LongevityClinical89Dose fit67Popularity50$1.20/ serving

7

Micro Ingredients, TUDCA, 240 Capsules

Micro IngredientsClinical35Dose fit9Popularity91$0.34/ serving

8

Revive, Liver, 120 Vegetarian Capsules

ReviveClinical35Dose fit9Popularity76$1.65/ serving

9

Nutricost, TUDCA, 250 mg, 60 Capsules

NutricostClinical21Dose fit4Popularity99$0.37/ serving

10

Best Naturals, TUDCA, 250 mg, 60 Capsules

Best NaturalsClinical21Dose fit4Popularity89$0.40/ serving

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

Comparison preview

Compare the top 3, side by side

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The top three for the current view — free to read, no account. Saving, exporting, alerts and the full filter set unlock once you sign in or build a personal report.

Metric

#1Nutricost, TUDCA, 500 mg, 30 CapsulesNutricost · $0.90/serving

#2Nutricost, TUDCA, Unflavored, 0.9 oz (25 g)Nutricost · $0.72/serving

#3Primaforce, TUDCA, 500 mg, 30 CapsulesPrimaforce · $0.73/serving

Composite838281

Clinical898989

Dose fit676767

Value505655

Popularity986876

Key dosages & price · raw values

500 mgHighest500 mgHighest500 mgHighest

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Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Relevant ingredients