Reduce liver injury risk

What this outcome means

Hepatotoxicity refers to clinically meaningful harm to the liver, the kind that shows up in blood markers or symptoms rather than a passing fluctuation. On DoseRank it maps to a defined health outcome built from human studies on serum ALT and AST, bilirubin levels, and clinical signs of liver damage – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Drug-load liversPeople on long medication regimens that put extra strain on the liver.

Elevated enzymesBlood tests showing liver enzymes climbing above the normal band.

Cautious by historyA past liver scare that makes you watchful about new exposures.

Stack buildersAlready taking supplements such as Silymarin and want the dose right.

Evidence level

78Moderate-strong

Silymarin – has moderate public evidence for this outcome. This usually means there are smaller or mechanistic studies, but not randomized human trials. A DoseFit Score of 92 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best available ingredients

Silymarin is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 92

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: Above range: Silymarin 2000 mg vs 420-1200 mg.

Processed

6.2k

Available

6.2k

Ingredients

Brands

491

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Reduce liver injury risk

What this outcome means

Who it's for

Drug-load liversPeople on long medication regimens that put extra strain on the liver.

Elevated enzymesBlood tests showing liver enzymes climbing above the normal band.

Cautious by historyA past liver scare that makes you watchful about new exposures.

Stack buildersAlready taking supplements such as Silymarin and want the dose right.

Evidence level

78Moderate-strong

Best available ingredients

Silymarin is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 92

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: Above range: Silymarin 2000 mg vs 420-1200 mg.

Processed

6.2k

Available

6.2k

Ingredients

Brands

491

Coverage

100%

Relevant ingredients

Which ingredient types matter for hepatotoxicity or liver injuryOpen to see which ingredient types matter for hepatotoxicity or liver injury

5.1k products across 4 ingredient types — open to filter the ranking.

Use types to filter ranked products

Antioxidants & Bioactive Compounds

69 products

Molecules that neutralize free radicals and tune cell signaling. Helpful in balance; mega-doses can blunt the body's own adaptive defenses.

Typical: ,

Botanicals/Herbal Extracts

2.1k products

Concentrated plant and herbal extracts standardized to actives. Potency depends on the extract ratio and marker content, not raw weight.

Typical: , , , ...

Vitamins

2.1k products

Essential micronutrients the body can't make in sufficient amounts. Fat-soluble ones (A, D, E, K) store up; water-soluble ones need regular topping-up.

Typical: ,

Amino Acids & Derivatives

871 products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical:

Top decision cards

Best products for hepatotoxicity or liver injury

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for hepatotoxicity or liver injury

Nature's Answer, Milk Thistle Seed, Fluid Extract, 2,000 mg, 2 fl oz (60 ml)

Nature's Answer$0.67 / serving4.8 · 6,025Available now

Why this ranks here

Evidence fitSilymarin has moderate human evidence for this outcome.
Dose fitSilymarin at 2000 mg is higher than the studied 420-1200 mg window.
Price / serving$0.67 per serving — high price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

Trade-offs

Value for money trails the rest of this list

The numbers

2000 mgAbove rangehigher than the studied 420-1200 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products