Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

Reduce liver injury risk

What this outcome means

Hepatotoxicity refers to clinically meaningful harm to the liver, the kind that shows up in blood markers or symptoms rather than a passing fluctuation. On DoseRank it maps to a defined health outcome built from human studies on serum ALT and AST, bilirubin levels, and clinical signs of liver damage – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Drug-load liversPeople on long medication regimens that put extra strain on the liver.

Elevated enzymesBlood tests showing liver enzymes climbing above the normal band.

Cautious by historyA past liver scare that makes you watchful about new exposures.

Stack buildersAlready taking supplements such as Silymarin and want the dose right.

Evidence level

78Moderate-strong

Silymarin – has moderate public evidence for this outcome. This usually means there are smaller or mechanistic studies, but not randomized human trials. A DoseFit Score of 72 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best available ingredients

Silymarin is the best supported ingredient signal for this outcome.

Dose partly matchedDoseFit 72

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Silymarin 600 mg vs 420-1200 mg.

Processed

Available

Ingredients

Brands

444

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Reduce liver injury risk

What this outcome means

Who it's for

Drug-load liversPeople on long medication regimens that put extra strain on the liver.

Elevated enzymesBlood tests showing liver enzymes climbing above the normal band.

Cautious by historyA past liver scare that makes you watchful about new exposures.

Stack buildersAlready taking supplements such as Silymarin and want the dose right.

Evidence level

78Moderate-strong

Best available ingredients

Silymarin is the best supported ingredient signal for this outcome.

Dose partly matchedDoseFit 72

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Silymarin 600 mg vs 420-1200 mg.

Processed

Available

Ingredients

Brands

444

Coverage

100%

Relevant ingredients

Which ingredient types matter for hepatotoxicity or liver injuryOpen to see which ingredient types matter for hepatotoxicity or liver injury

3.1k products across 4 ingredient types — open to filter the ranking.

Use types to filter ranked products

Antioxidants & Bioactive Compounds

30 products

Molecules that neutralize free radicals and tune cell signaling. Helpful in balance; mega-doses can blunt the body's own adaptive defenses.

Typical: ,

Botanicals/Herbal Extracts

667 products

Concentrated plant and herbal extracts standardized to actives. Potency depends on the extract ratio and marker content, not raw weight.

Typical: , , , ...

Vitamins

1.9k products

Essential micronutrients the body can't make in sufficient amounts. Fat-soluble ones (A, D, E, K) store up; water-soluble ones need regular topping-up.

Typical: ,

Amino Acids & Derivatives

555 products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical:

Top decision cards

Best products for hepatotoxicity or liver injury

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for hepatotoxicity or liver injury

NOW Foods, Milk Thistle Extract, 750 mg, 90 Veg Capsules

NOW Foods$0.26 / serving4.8 · 4,087Available now

Also helps with

Aspartate aminotransferase (AST)

Alanine aminotransferase (ALT)

Liver function

Why this ranks here

Evidence fitSilymarin has moderate human evidence for this outcome.
Dose fitSilymarin at 600 mg lands inside the studied 420-1200 mg window.
Price / serving$0.26 per serving — mid price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

600 mgIn rangeinside the studied 420-1200 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

Futurebiotics, Silymarin Plus™, 120 Vegetarian Tablets

FuturebioticsClinical86Dose fit67Popularity30$0.47/ serving

Planetary Herbals, Full Spectrum™ Milk Thistle Seed Extract, 120 Tablets

Planetary HerbalsClinical86Dose fit67Popularity30$0.44/ serving

Zhou Nutrition, Milk Thistle, 60 Veggie Capsules (450 mg per Capsule)

Zhou NutritionClinical86Dose fit67Popularity30$0.82/ serving

NutraBio, Liver, 90 Capsules

NutraBioClinical86Dose fit67Popularity30$1.65/ serving

NaturesPlus, Herbal Actives, Milk Thistle, Extended Release, 500 mg, 30 Tablets

NaturesPlusClinical81Dose fit55Popularity30$0.89/ serving

Metabolic Maintenance, Metabolic Detox®, 60 Vegetarian Capsules

Metabolic MaintenanceClinical81Dose fit55Popularity30$1.36/ serving

Vitacost, Synergy®, GlucoPower® Multivitamin, 240 Capsules

VitacostClinical81Dose fit55Popularity30$1.05/ serving

Gaia Herbs, Milk Thistle, 120 Vegan Capsules

Gaia HerbsClinical74Dose fit42Popularity68$1.15/ serving

Solgar, Milk Thistle, 250 Vegetable Capsules (450 mg per Capsule)

SolgarClinical70Dose fit36Popularity50$0.14/ serving