DOSERANKEVIDENCE-BASED SUPPLEMENTS
DOSERANKEVIDENCE-BASED SUPPLEMENTS© 2026 DoseRank · Evidence-based supplements
Methodology·Outcomes·Categories
DOSERANKEVIDENCE-BASED SUPPLEMENTS
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  1. Search
  2. ·Outcomes
  3. ·Muscle health
  4. ·Sarcopenia status

Reduce sarcopenia

View top productsTake the 60-sec quizGet the reportSee methodology

What this outcome means

Sarcopenia status reflects whether muscle mass and strength have declined enough to affect how you move and function. On DoseRank it maps to a defined health outcome built from human studies on muscle mass measures, grip strength, and gait speed – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Aging muscleOlder adults noticing weaker, smaller muscles year over year.
Weak gripPeople struggling with strength tasks like carrying or rising from a chair.
Slowing mobilityThose whose walking pace and steadiness have gradually declined.
Stack buildersAlready taking supplements such as L-Leucine and want the dose right.

Evidence level

92Strong

L-Leucine – has strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 82 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

L-Leucine is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 82

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: Below range: L-Leucine 5 g vs 3000-6000 g.

ProcessedProcessedEvery product DoseRank ingested and scored for this outcome, before any availability or relevance filtering.
1.5k
AvailableAvailableOf the products processed, how many are currently in stock and purchasable from a tracked retailer.
1.5k
IngredientsIngredientsNumber of relevant ingredients for this outcome. Each is judged on its own evidence and dose fit score.
3
BrandsBrandsNumber of unique brands represented across the ranked products for this outcome.
203
CoverageCoverageHigher is betterShare of the relevant, in-stock market DoseRank has structured data for. Higher coverage means fewer blind spots in the ranking.
100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.
CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better
ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better
EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better
ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better
TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better
PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Relevant ingredients

Which ingredient types matter for sarcopenia statusOpen to see which ingredient types matter for sarcopenia status

1.5k products across 1 ingredient types — open to filter the ranking.
Use types to filter ranked products

Amino Acids & Derivatives

1.5k products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical: ,

Top decision cards

Best products for sarcopenia status

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for sarcopenia status

#1

Nutricost, L-Leucine, Unflavored, 17.9 oz (500 g)

Nutricost$0.20 / serving4.7 · 363Available now

Why this ranks here

  • Evidence fitL-Leucine is the strongest evidence signal for this outcome.
  • Dose fitL-Leucine at 5 g sits below the studied 3000-6000 mg window.
  • Price / serving$0.20 per serving — low price tier for this outcome.
  • AvailabilityIn stock across major retailers; 99% availability confidence.
  • TrustMixed trust signals — ratings are positive but the base is limited.

Trade-offs

Trust signals sit below the other picks

The numbers

84
88
82
88

5 gBelow rangebelow the studied 3000-6000 mg window
Compare top 3Product dataOpen at retailer

The rest of the ranking · DoseRank

Top 10 ranked products
#ProductPrice

Keep exploring

Related outcomes

Muscle crampsPainful involuntary muscle contractions.Muscle massQuantity of skeletal muscle tissue.Muscle strengthAbility of muscles to generate force.Muscle weaknessReduced ability to generate force.
Last updated Jun 12, 2026

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Comparison preview

Compare the top 3, side by side

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The top three for the current view — free to read, no account. Saving, exporting, alerts and the full filter set unlock once you sign in or build a personal report.

Metric
#1Nutricost, L-Leucine, Unflavored, 17.9 oz (500 g)Nutricost · $0.20/serving
#2MuscleMeds, Carnivor Beef Aminos, 100% Pure Beef Protein, 300 TabletsMuscleMeds · $0.22/serving
#3XTEND, Sport®, 7G BCAA, Blue Raspberry Ice, 12.2 oz (345 g)XTEND · $0.66/serving
Composite848382
Clinical888786
Dose fit827671
Value888769
Popularity807583
Key dosages & price · raw values
5 gHighest——
Rating
Number of ratings
Price
Price per serving
Serving size
Trust

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Unlocks with accountFull list of ingredients and dosagesFull list of metricsPrice-drop alertsRanking-changes alertsPersistent stack