Increase HDL cholesterol

What this outcome means

HDL cholesterol is the so-called good cholesterol that helps shuttle excess cholesterol out of your bloodstream, and on a lipid panel higher levels are usually viewed favorably. On DoseRank it maps to a defined health outcome built from human studies on HDL-C blood concentrations, the total-to-HDL cholesterol ratio, and lipid panel measures – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Low-HDL readingsPanels showing good cholesterol sitting under the preferred range.

Heart-health focusedPeople watching cholesterol ratios as part of cardiovascular care.

Sedentary lifestylesThose whose limited activity tends to keep HDL low.

Stack buildersAlready taking supplements such as Niacin or Vitamin B3 and want the dose right.

Evidence level

92Strong

Niacin and Vitamin B3 – have strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 67 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

Niacin and Vitamin B3 are the best supported ingredient signals for this outcome.

Dose partly matchedDoseFit 67

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Niacin 500 mg vs 500-3000 mg; Below range: Vitamin B3 500 mg vs 1000-3000 mg.

Processed

4.4k

Available

4.4k

Ingredients

Brands

464

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Increase HDL cholesterol

What this outcome means

Who it's for

Low-HDL readingsPanels showing good cholesterol sitting under the preferred range.

Heart-health focusedPeople watching cholesterol ratios as part of cardiovascular care.

Sedentary lifestylesThose whose limited activity tends to keep HDL low.

Stack buildersAlready taking supplements such as Niacin or Vitamin B3 and want the dose right.

Evidence level

92Strong

Best ingredients

Niacin and Vitamin B3 are the best supported ingredient signals for this outcome.

Dose partly matchedDoseFit 67

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Niacin 500 mg vs 500-3000 mg; Below range: Vitamin B3 500 mg vs 1000-3000 mg.

Processed

4.4k

Available

4.4k

Ingredients

Brands

464

Coverage

100%

Relevant ingredients

Which ingredient types matter for hdl cholesterolOpen to see which ingredient types matter for hdl cholesterol

969 products across 1 ingredient types — open to filter the ranking.

Use types to filter ranked products

Vitamins

969 products

Essential micronutrients the body can't make in sufficient amounts. Fat-soluble ones (A, D, E, K) store up; water-soluble ones need regular topping-up.

Typical: ,

Top decision cards

Best products for hdl cholesterol

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for hdl cholesterol

Life Extension, Vitamin B3 Niacin, 500 mg, 100 Capsules

Life Extension$0.05 / serving4.6 · 8,772Available now

Why this ranks here

Evidence fitNiacin and Vitamin B3 are the strongest evidence signals for this outcome.
Dose fit1 of 2 dosed ingredients land in the studied range. Niacin at 500 mg lands inside the studied 500-3000 mg window.
Price / serving$0.05 per serving — mid price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

Trade-offs

Dose fit is the weak spot on this list

The numbers

500 mgIn rangeinside the studied 500-3000 mg window

500 mgBelow rangebelow the studied 1000-3000 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products