Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

Lower total cholesterol

What this outcome means

Total cholesterol is the overall amount of cholesterol circulating in your blood, a number drawn from a standard lipid panel. On DoseRank it maps to a defined health outcome built from human studies on serum total cholesterol concentration, lipid-panel readings, and changes over time – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Borderline readingsPeople whose lipid panel sits just above the preferred range.

Family lipid historyThose with relatives who run high cholesterol numbers.

Tracking lab trendsAnyone watching their cholesterol figure across repeat blood tests.

Stack buildersAlready taking supplements such as Beta-Sitosterol or Pantethine and want the dose right.

Evidence level

89Strong

Beta-Sitosterol, Pantethine, and Artichoke Extract – have strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 69 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

Beta-Sitosterol, Pantethine, and Artichoke Extract are the best supported ingredient signals for this outcome.

Dose partly matchedDoseFit 69

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Beta-Sitosterol 2 g vs 0.8-3 g, Artichoke Extract 500 mg vs 500-2000 mg; Below range: Pantethine 500 mg vs 600-1200 mg.

Processed

2.7k

Available

2.7k

Ingredients

Brands

321

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

Not sure which is right for you?

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Take 60-sec quiz

Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Lower total cholesterol

What this outcome means

Who it's for

Borderline readingsPeople whose lipid panel sits just above the preferred range.

Family lipid historyThose with relatives who run high cholesterol numbers.

Tracking lab trendsAnyone watching their cholesterol figure across repeat blood tests.

Stack buildersAlready taking supplements such as Beta-Sitosterol or Pantethine and want the dose right.

Evidence level

89Strong

Best ingredients

Beta-Sitosterol, Pantethine, and Artichoke Extract are the best supported ingredient signals for this outcome.

Dose partly matchedDoseFit 69

Processed

2.7k

Available

2.7k

Ingredients

Brands

321

Coverage

100%

Relevant ingredients

Which ingredient types matter for total cholesterolOpen to see which ingredient types matter for total cholesterol

80 products across 2 ingredient types — open to filter the ranking.

Use types to filter ranked products

Fibers & Prebiotics

28 products

Indigestible carbs that feed gut bacteria and add bulk. Start low and ramp slowly – too much too fast means bloating and gas.

Typical: ,

Adsorbents & Inert Functional Materials

52 products

Binding agents like charcoal and silica that adsorb or stabilize. Functional and non-nutritive – they can bind nutrients, so time them apart.

Typical:

Top decision cards

Best products for total cholesterol

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for total cholesterol

Revive, Lipid, 210 Tablets

Revive$1.65 / serving4.7 · 94Available now

Also helps with

Urinary frequency

LDL cholesterol

Urinary tract symptoms

Why this ranks here

Evidence fitBeta-Sitosterol and Pantethine are the strongest evidence signals for this outcome.
Dose fit2 of 3 dosed ingredients land in the studied range. Beta-Sitosterol at 2 g lands inside the studied 0.8-3 g window.
Price / serving$1.65 per serving — high price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustLimited trust signals so far for this listing.

The numbers

2 gIn rangeinside the studied 0.8-3 g window

500 mgBelow rangebelow the studied 600-1200 mg window

500 mgIn rangeinside the studied 500-2000 mg window

100 mg

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

NOW Foods, Pantethine, 600 mg, 60 Softgels

NOW FoodsClinical69Dose fit67Popularity80$0.48/ serving

Metagenics, UltraMeal Cardio 360°®, Medical Food, Vanilla, 1 lb 2.27 oz (518 g)

MetagenicsClinical74Dose fit39Popularity30$4.88/ serving

NOW Foods, Glucomannan, Pure Powder, 8 oz (227 g)

NOW FoodsClinical42Dose fit13Popularity76$0.14/ serving

Nutricost, Glucomannan, Unflavored, 17.9 oz (500 g)

NutricostClinical42Dose fit13Popularity50$0.10/ serving

Nature's Way, Glucomannan from Konjac Root, 100 Vegan Capsules (665 mg per Capsule)

Nature's WayClinical42Dose fit13Popularity76$0.34/ serving

Best Naturals, Konjac Root Glucomannan, 1 lb (454 g)

Best NaturalsClinical42Dose fit13Popularity30$0.11/ serving

Best Naturals, Konjac Root, 180 Vegetarian Capsules (666 mg per Capsule)

Best NaturalsClinical42Dose fit13Popularity50$0.19/ serving

Vitacost, Glucomannan, 180 Capsules (666 mg per Capsule)

VitacostClinical42Dose fit13Popularity30$0.20/ serving

Natural Balance, Glucomannan™, Maximum Strength, 90 Capsules (666 mg per Capsule)

Natural BalanceClinical42Dose fit13Popularity30$0.55/ serving