Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

Improve endothelial function

What this outcome means

Endothelial function is how well the thin lining of your blood vessels widens and adjusts so blood flows smoothly as demands change. On DoseRank it maps to a defined health outcome built from human studies on flow-mediated dilation, vascular reactivity, and arterial stiffness – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Heart-health mindedWatching cardiovascular markers and how freely blood moves through vessels.

Sedentary and desk-boundLong sitting hours that leave circulation sluggish through the day.

Aging vesselsOlder adults noticing arteries feel stiffer and less responsive.

Stack buildersAlready taking supplements such as Pine Bark Extract and want the dose right.

Evidence level

92Strong

Pine Bark Extract – has strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 91 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

Pine Bark Extract is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 91

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: Above range: Pine Bark Extract 300 mg vs 100-200 mg.

Processed

6.2k

Available

6.2k

Ingredients

Brands

464

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

Not sure which is right for you?

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Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Improve endothelial function

What this outcome means

Who it's for

Heart-health mindedWatching cardiovascular markers and how freely blood moves through vessels.

Sedentary and desk-boundLong sitting hours that leave circulation sluggish through the day.

Aging vesselsOlder adults noticing arteries feel stiffer and less responsive.

Stack buildersAlready taking supplements such as Pine Bark Extract and want the dose right.

Evidence level

92Strong

Best ingredients

Pine Bark Extract is the best supported ingredient signal for this outcome.

Dose matchedDoseFit 91

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: Above range: Pine Bark Extract 300 mg vs 100-200 mg.

Processed

6.2k

Available

6.2k

Ingredients

Brands

464

Coverage

100%

Relevant ingredients

Which ingredient types matter for endothelial functionOpen to see which ingredient types matter for endothelial function

5.9k products across 5 ingredient types — open to filter the ranking.

Use types to filter ranked products

Botanicals/Herbal Extracts

573 products

Concentrated plant and herbal extracts standardized to actives. Potency depends on the extract ratio and marker content, not raw weight.

Typical: , , , ...

Amino Acids & Derivatives

135 products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical: ,

Antioxidants & Bioactive Compounds

840 products

Molecules that neutralize free radicals and tune cell signaling. Helpful in balance; mega-doses can blunt the body's own adaptive defenses.

Typical: , ,

Fatty Acids & Lipids

5 products

Dietary fats including omega-3s and structural lipids. Look at the active EPA/DHA amounts and freshness, since oils oxidize and turn rancid.

Typical:

Vitamins

4.4k products

Essential micronutrients the body can't make in sufficient amounts. Fat-soluble ones (A, D, E, K) store up; water-soluble ones need regular topping-up.

Top decision cards

Best products for endothelial function

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for endothelial function

Nutricost, Pine Bark Extract, 180 Capsules (300 mg per Capsule)

Nutricost$0.07 / serving4.7 · 1,668Available now

Also helps with

Antioxidant capacity

Asthma control

Blood pressure

Why this ranks here

Evidence fitPine Bark Extract is the strongest evidence signal for this outcome.
Dose fitPine Bark Extract at 300 mg is higher than the studied 100-200 mg window.
Price / serving$0.07 per serving — low price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustSolid trust signals from buyer ratings, with room to grow.

The numbers

300 mgAbove rangehigher than the studied 100-200 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

Force Factor, Total Beets®, Pre-Workout, Fruit Punch, 12.6 oz (356 g)

Force FactorClinical96Dose fit67Popularity30$0.90/ serving

Nutricost, L-Citrulline, Unflavored , 1.3 lb (600 g)

NutricostClinical86Dose fit67Popularity96$0.13/ serving

NOW Foods, Pine Bark Extract, 240 mg, 90 Veg Capsules

NOW FoodsClinical87Dose fit91Popularity80$0.17/ serving

Doctor's Best, L-Citrulline Powder, 7 oz (200 g)

Doctor's BestClinical86Dose fit67Popularity96$0.30/ serving

Source Naturals, Pine Bark Extract, 60 Tablets

Source NaturalsClinical87Dose fit91Popularity80$0.25/ serving

EVLution Nutrition, Pine Bark Extract, 90 Veggie Capsules (240 mg per Capsule)

EVLution NutritionClinical87Dose fit91Popularity50$0.07/ serving

California Gold Nutrition, Resveratrol Complex with Grape Seed Extract, Red Wine Extract, and trans-Resveratrol, 60 Veggie Capsules

California Gold NutritionClinical83Dose fit90Popularity99$0.14/ serving

California Gold Nutrition, French Maritime Pine Bark Extract, Oligopin, 100 mg, 180 Veggie Capsules

California Gold NutritionClinical84Dose fit67Popularity89$0.39/ serving

MRM Nutrition, DRIVEN™, Pre-Workout Boost, Mixed Berries, 12.3 oz (350 g)

MRM NutritionClinical89Dose fit55Popularity50$0.71/ serving