How does DoseRank decide what ranks #1?

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

DOSERANKEVIDENCE-BASED SUPPLEMENTS

Reduce irritability

DOSERANKEVIDENCE-BASED SUPPLEMENTS

Best Supplements for Irritability — 435 Ranked by Evidence | DOSERANK

Top decision cards

Best products for irritability

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for irritability

Nature's Way, Vitex Fruit, 400 mg, 100 Vegan Capsules

Nature's Way$0.06 / serving4.6 · 28,086Available now

Also helps with

Menstrual regularity

Premenstrual symptom severity

Female fertility

Why this ranks here

Evidence fitChasteberry (Vitex) is the strongest evidence signal for this outcome.
Dose fitChasteberry (Vitex) at 400 mg lands inside the studied 20-800 mg window.
Price / serving$0.06 per serving — low price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

400 mgIn rangeinside the studied 20-800 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

Solaray, True Herbs, Vitex, 400 mg, 100 VegCaps

SolarayClinical88Dose fit78Popularity89$0.09/ serving

Swanson Vitamins, Full Spectrum® Chasteberry Fruit, 400 mg, 120 Vegan Capsules

Swanson VitaminsClinical88Dose fit78Popularity91$0.08/ serving

NOW Foods, Chaste Berry Vitex Extract, 300 mg, 90 Veg Capsules

NOW FoodsClinical88Dose fit75Popularity84$0.15/ serving

Nature's Answer, Vitex, 40 mg, 90 Vegetarian Capsules

Nature's AnswerClinical87Dose fit67Popularity68$0.10/ serving

Swanson Vitamins, Menopause Essentials, Women's Health, 120 Veggie Capsules

Swanson VitaminsClinical87Dose fit68Popularity80$0.12/ serving

EVLution Nutrition, Women's Multivitamin, 120 Tablets

EVLution NutritionClinical87Dose fit68Popularity68$0.23/ serving

Nutricost, Women, Chasteberry with Dong Quai & Ginger Root, 120 Capsules

NutricostClinical89Dose fit81Popularity50$0.13/ serving

NOW Foods, Female Balance™, 90 Veg Capsules

NOW FoodsClinical87Dose fit69Popularity68$0.17/ serving

NOW Foods, Menopause Support, 90 Veg Capsules

NOW FoodsClinical87Dose fit69Popularity91$0.48/ serving

Top decision cards

Best products for irritability

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for irritability

Nature's Way, Vitex Fruit, 400 mg, 100 Vegan Capsules

Nature's Way$0.06 / serving4.6 · 28,086Available now

Also helps with

Menstrual regularity

Premenstrual symptom severity

Female fertility

Why this ranks here

Evidence fitChasteberry (Vitex) is the strongest evidence signal for this outcome.
Dose fitChasteberry (Vitex) at 400 mg lands inside the studied 20-800 mg window.
Price / serving$0.06 per serving — low price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

400 mgIn rangeinside the studied 20-800 mg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

Solaray, True Herbs, Vitex, 400 mg, 100 VegCaps

SolarayClinical88Dose fit78Popularity89$0.09/ serving

Swanson Vitamins, Full Spectrum® Chasteberry Fruit, 400 mg, 120 Vegan Capsules

Swanson VitaminsClinical88Dose fit78Popularity91$0.08/ serving

NOW Foods, Chaste Berry Vitex Extract, 300 mg, 90 Veg Capsules

NOW FoodsClinical88Dose fit75Popularity84$0.15/ serving

Nature's Answer, Vitex, 40 mg, 90 Vegetarian Capsules

Nature's AnswerClinical87Dose fit67Popularity68$0.10/ serving

Swanson Vitamins, Menopause Essentials, Women's Health, 120 Veggie Capsules

Swanson VitaminsClinical87Dose fit68Popularity80$0.12/ serving

EVLution Nutrition, Women's Multivitamin, 120 Tablets

EVLution NutritionClinical87Dose fit68Popularity68$0.23/ serving

Nutricost, Women, Chasteberry with Dong Quai & Ginger Root, 120 Capsules

NutricostClinical89Dose fit81Popularity50$0.13/ serving

NOW Foods, Female Balance™, 90 Veg Capsules

NOW FoodsClinical87Dose fit69Popularity68$0.17/ serving

NOW Foods, Menopause Support, 90 Veg Capsules

NOW FoodsClinical87Dose fit69Popularity91$0.48/ serving

Reduce irritability

Reduce irritability

Which ingredient types matter for irritabilityOpen to see which ingredient types matter for irritability

Botanicals/Herbal Extracts

Minerals & Trace Elements

Antioxidants & Bioactive Compounds

Best products for irritability

Nature's Way, Vitex Fruit, 400 mg, 100 Vegan Capsules

Solaray, True Herbs, Vitex, 400 mg, 100 VegCaps

Swanson Vitamins, Full Spectrum® Chasteberry Fruit, 400 mg, 120 Vegan Capsules

NOW Foods, Chaste Berry Vitex Extract, 300 mg, 90 Veg Capsules

Nature's Answer, Vitex, 40 mg, 90 Vegetarian Capsules

Swanson Vitamins, Menopause Essentials, Women's Health, 120 Veggie Capsules

EVLution Nutrition, Women's Multivitamin, 120 Tablets

Nutricost, Women, Chasteberry with Dong Quai & Ginger Root, 120 Capsules

NOW Foods, Female Balance™, 90 Veg Capsules

NOW Foods, Menopause Support, 90 Veg Capsules

What every metric means

Compare the top 3, side by side

Not sure which is right for you?

Get a personal report

Frequently asked

Which ingredient types matter for irritabilityOpen to see which ingredient types matter for irritability

Botanicals/Herbal Extracts

Minerals & Trace Elements

Antioxidants & Bioactive Compounds

Compare the top 3, side by side

Best products for irritability

Nature's Way, Vitex Fruit, 400 mg, 100 Vegan Capsules

Solaray, True Herbs, Vitex, 400 mg, 100 VegCaps

Swanson Vitamins, Full Spectrum® Chasteberry Fruit, 400 mg, 120 Vegan Capsules

NOW Foods, Chaste Berry Vitex Extract, 300 mg, 90 Veg Capsules

Nature's Answer, Vitex, 40 mg, 90 Vegetarian Capsules

Swanson Vitamins, Menopause Essentials, Women's Health, 120 Veggie Capsules

EVLution Nutrition, Women's Multivitamin, 120 Tablets

Nutricost, Women, Chasteberry with Dong Quai & Ginger Root, 120 Capsules

NOW Foods, Female Balance™, 90 Veg Capsules

NOW Foods, Menopause Support, 90 Veg Capsules