Lower homocysteine

What this outcome means

Homocysteine is an amino acid in your blood whose level reflects how well your body runs certain methylation pathways and is tied to vascular health. On DoseRank it maps to a defined health outcome built from human studies on plasma homocysteine concentration, methylation status, and related vascular risk markers – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Raised on labsA blood test flagging homocysteine above the usual reference range.

Heart-history watchersA family or personal vascular history that keeps you tracking this marker.

Methylation mindedPeople tracking how well their body clears and recycles homocysteine.

Stack buildersAlready taking supplements such as L-Methylfolate or Methylcobalamin and want the dose right.

Evidence level

92Strong

L-Methylfolate and Methylcobalamin – have strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 78 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

L-Methylfolate and Methylcobalamin are the best supported ingredient signals for this outcome.

Dose matchedDoseFit 78

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: L-Methylfolate 680 mcg vs 400-1000 mcg; Below range: Methylcobalamin 300 mcg vs 500-2000 mcg.

Processed

5.7k

Available

5.7k

Ingredients

Brands

448

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Lower homocysteine

What this outcome means

Who it's for

Raised on labsA blood test flagging homocysteine above the usual reference range.

Heart-history watchersA family or personal vascular history that keeps you tracking this marker.

Methylation mindedPeople tracking how well their body clears and recycles homocysteine.

Stack buildersAlready taking supplements such as L-Methylfolate or Methylcobalamin and want the dose right.

Evidence level

92Strong

Best ingredients

L-Methylfolate and Methylcobalamin are the best supported ingredient signals for this outcome.

Dose matchedDoseFit 78

Processed

5.7k

Available

5.7k

Ingredients

Brands

448

Coverage

100%

Relevant ingredients

Which ingredient types matter for homocysteineOpen to see which ingredient types matter for homocysteine

5.6k products across 2 ingredient types — open to filter the ranking.

Use types to filter ranked products

Amino Acids & Derivatives

871 products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical:

Vitamins

4.8k products

Essential micronutrients the body can't make in sufficient amounts. Fat-soluble ones (A, D, E, K) store up; water-soluble ones need regular topping-up.

Typical: , , , ...

Top decision cards

Best products for homocysteine

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for homocysteine

Life Extension, BioActive Folate & Vitamin B12, 90 Vegetarian Capsules

Life Extension$0.09 / serving4.8 · 8,042Available now

Why this ranks here

Evidence fitL-Methylfolate and Methylcobalamin are the strongest evidence signals for this outcome.
Dose fit1 of 2 dosed ingredients land in the studied range. L-Methylfolate at 680 mcg lands inside the studied 400-1000 µg window.
Price / serving$0.09 per serving — low price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

Trade-offs

Dose fit is the weak spot on this listValue for money trails the rest of this list

The numbers

680 mcgIn rangeinside the studied 400-1000 µg window

300 mcgBelow rangebelow the studied 500-2000 µg window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products