How does DoseRank decide what ranks #1?

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Is a higher dose always better?

No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.

What does the Value score mean?

The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.

Why is the cheapest product not #1?

Cost is only one input. The cheapest pick here is a citrate form with weaker absorption and a stock-risk flag, so it leads on Value-for-cost but trails on the composite that also weighs evidence, dose fit and availability.

Are these affiliate links?

Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.

Is this medical advice?

No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.

DOSERANKEVIDENCE-BASED SUPPLEMENTS

Improve folate status

DOSERANKEVIDENCE-BASED SUPPLEMENTS

Best Supplements for Folate status — 2913 Ranked | DOSERANK

Top decision cards

Best products for folate status

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for folate status

Life Extension, BioActive Folate & Vitamin B12, 90 Vegetarian Capsules

Life Extension$0.09 / serving4.8 · 8,146Available now

Also helps with

Congenital anomaly

Homocysteine

Why this ranks here

Evidence fitCalcium L-Methylfolate is the strongest evidence signal for this outcome.
Dose fitCalcium L-Methylfolate at 680 mcg lands inside the studied 400-1000 mcg window.
Price / serving$0.09 per serving — low price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

680 mcgIn rangeinside the studied 400-1000 mcg window

300 mcg

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

Life Extension, Optimized Folate, 1,700 mcg DFE, 100 Vegetarian Tablets

Life ExtensionClinical89Dose fit92Popularity96$0.10/ serving

NaturesPlus, Folic Acid as Methylfolate , 800 mcg, 90 Tablets

NaturesPlusClinical89Dose fit82Popularity80$0.08/ serving

Solgar, Folate, 666 mcg DFE, 100 Tablets

SolgarClinical89Dose fit67Popularity84$0.10/ serving

California Gold Nutrition, Vitamin B Complex with Folate, Biotin, Pantothenic Acid, and Vitamin B6, 60 Veggie Capsules

California Gold NutritionClinical88Dose fit67Popularity99$0.16/ serving

Life Extension, BioActive Complete B-Complex, 60 Vegetarian Capsules

Life ExtensionClinical89Dose fit78Popularity100$0.27/ serving

Life Extension, Two-Per-Day Multivitamin, 120 Tablets

Life ExtensionClinical89Dose fit78Popularity99$0.28/ serving

Zahler, Iron Complex, 100 Capsules

ZahlerClinical88Dose fit67Popularity84$0.15/ serving

Life Extension, Homocysteine Resist, 60 Vegetarian Capsules

Life ExtensionClinical89Dose fit99Popularity91$0.29/ serving

Paradise Herbs, Earth's Blend®, One Daily Superfood Multi-Vitamin, No Iron, 120 Vegetarian Capsules

Paradise HerbsClinical89Dose fit67Popularity91$0.22/ serving

Top decision cards

Best products for folate status

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for folate status

Life Extension, BioActive Folate & Vitamin B12, 90 Vegetarian Capsules

Life Extension$0.09 / serving4.8 · 8,146Available now

Also helps with

Congenital anomaly

Homocysteine

Why this ranks here

Evidence fitCalcium L-Methylfolate is the strongest evidence signal for this outcome.
Dose fitCalcium L-Methylfolate at 680 mcg lands inside the studied 400-1000 mcg window.
Price / serving$0.09 per serving — low price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustStrong trust signals — consistently high marks from verified buyer ratings.

The numbers

680 mcgIn rangeinside the studied 400-1000 mcg window

300 mcg

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products

Life Extension, Optimized Folate, 1,700 mcg DFE, 100 Vegetarian Tablets

Life ExtensionClinical89Dose fit92Popularity96$0.10/ serving

NaturesPlus, Folic Acid as Methylfolate , 800 mcg, 90 Tablets

NaturesPlusClinical89Dose fit82Popularity80$0.08/ serving

Solgar, Folate, 666 mcg DFE, 100 Tablets

SolgarClinical89Dose fit67Popularity84$0.10/ serving

California Gold Nutrition, Vitamin B Complex with Folate, Biotin, Pantothenic Acid, and Vitamin B6, 60 Veggie Capsules

California Gold NutritionClinical88Dose fit67Popularity99$0.16/ serving

Life Extension, BioActive Complete B-Complex, 60 Vegetarian Capsules

Life ExtensionClinical89Dose fit78Popularity100$0.27/ serving

Life Extension, Two-Per-Day Multivitamin, 120 Tablets

Life ExtensionClinical89Dose fit78Popularity99$0.28/ serving

Zahler, Iron Complex, 100 Capsules

ZahlerClinical88Dose fit67Popularity84$0.15/ serving

Life Extension, Homocysteine Resist, 60 Vegetarian Capsules

Life ExtensionClinical89Dose fit99Popularity91$0.29/ serving

Paradise Herbs, Earth's Blend®, One Daily Superfood Multi-Vitamin, No Iron, 120 Vegetarian Capsules

Paradise HerbsClinical89Dose fit67Popularity91$0.22/ serving

Improve folate status

Improve folate status

Which ingredient types matter for folate statusOpen to see which ingredient types matter for folate status

Vitamins

Best products for folate status

Life Extension, BioActive Folate & Vitamin B12, 90 Vegetarian Capsules

Life Extension, Optimized Folate, 1,700 mcg DFE, 100 Vegetarian Tablets

NaturesPlus, Folic Acid as Methylfolate , 800 mcg, 90 Tablets

Solgar, Folate, 666 mcg DFE, 100 Tablets

California Gold Nutrition, Vitamin B Complex with Folate, Biotin, Pantothenic Acid, and Vitamin B6, 60 Veggie Capsules

Life Extension, BioActive Complete B-Complex, 60 Vegetarian Capsules

Life Extension, Two-Per-Day Multivitamin, 120 Tablets

Zahler, Iron Complex, 100 Capsules

Life Extension, Homocysteine Resist, 60 Vegetarian Capsules

Paradise Herbs, Earth's Blend®, One Daily Superfood Multi-Vitamin, No Iron, 120 Vegetarian Capsules

What every metric means

Compare the top 3, side by side

Not sure which is right for you?

Get a personal report

Frequently asked

Which ingredient types matter for folate statusOpen to see which ingredient types matter for folate status

Vitamins

Compare the top 3, side by side

Best products for folate status

Life Extension, BioActive Folate & Vitamin B12, 90 Vegetarian Capsules

Life Extension, Optimized Folate, 1,700 mcg DFE, 100 Vegetarian Tablets

NaturesPlus, Folic Acid as Methylfolate , 800 mcg, 90 Tablets

Solgar, Folate, 666 mcg DFE, 100 Tablets

California Gold Nutrition, Vitamin B Complex with Folate, Biotin, Pantothenic Acid, and Vitamin B6, 60 Veggie Capsules

Life Extension, BioActive Complete B-Complex, 60 Vegetarian Capsules

Life Extension, Two-Per-Day Multivitamin, 120 Tablets

Zahler, Iron Complex, 100 Capsules

Life Extension, Homocysteine Resist, 60 Vegetarian Capsules

Paradise Herbs, Earth's Blend®, One Daily Superfood Multi-Vitamin, No Iron, 120 Vegetarian Capsules