DOSERANKEVIDENCE-BASED SUPPLEMENTS
DOSERANKEVIDENCE-BASED SUPPLEMENTS© 2026 DoseRank · Evidence-based supplements
Methodology·Outcomes·Categories
DOSERANKEVIDENCE-BASED SUPPLEMENTS
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  1. Search
  2. ·Outcomes
  3. ·Cardiovascular event risk
  4. ·Major adverse cardiovascular events

Reduce major cardiovascular events

View top productsTake the 60-sec quizGet the reportSee methodology

What this outcome means

Major adverse cardiovascular events group together the serious cardiac outcomes — like heart attack, stroke, or cardiac death — that doctors watch most closely. On DoseRank it maps to a defined health outcome built from human studies on event incidence rates, hospitalization frequency, and survival outcomes – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

Established heart diseaseAlready diagnosed and working to avoid another event.
Stacked risk factorsBlood pressure, diabetes, and cholesterol pushing risk upward.
Post-event survivorsRecovering from a heart attack or stroke and guarding against the next.
Stack buildersAlready taking supplements such as Eicosapentaenoic Acid (EPA) or Triglyceride Omega-3 and want the dose right.

Evidence level

92Strong

Eicosapentaenoic Acid (EPA) and Triglyceride Omega-3 – have strong public evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 76 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

Eicosapentaenoic Acid (EPA) and Triglyceride Omega-3 are the best supported ingredient signals for this outcome.

Dose matchedDoseFit 76

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: Eicosapentaenoic Acid (EPA) 2820 mg vs 2000-4000 mg; Below range: Triglyceride Omega-3 2.8 g vs 2000-4000 g.

ProcessedProcessedEvery product DoseRank ingested and scored for this outcome, before any availability or relevance filtering.
1.2k
AvailableAvailableOf the products processed, how many are currently in stock and purchasable from a tracked retailer.
1.2k
IngredientsIngredientsNumber of relevant ingredients for this outcome. Each is judged on its own evidence and dose fit score.
5
BrandsBrandsNumber of unique brands represented across the ranked products for this outcome.
160
CoverageCoverageHigher is betterShare of the relevant, in-stock market DoseRank has structured data for. Higher coverage means fewer blind spots in the ranking.
100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.
CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better
ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better
EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better
ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better
TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better
PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

Not sure which is right for you?

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Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Relevant ingredients

Which ingredient types matter for major adverse cardiovascular eventsOpen to see which ingredient types matter for major adverse cardiovascular events

981 products across 1 ingredient types — open to filter the ranking.
Use types to filter ranked products

Fatty Acids & Lipids

981 products

Dietary fats including omega-3s and structural lipids. Look at the active EPA/DHA amounts and freshness, since oils oxidize and turn rancid.

Typical:

Top decision cards

Best products for major adverse cardiovascular events

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for major adverse cardiovascular events

#1

Metagenics, OmegaGenics®, Fish Oil EPA-DHA Liquid, Natural Lemon, 5 fl oz (150 ml)

Metagenics$1.73 / serving4.9 · 72Available now

Why this ranks here

  • Evidence fitEicosapentaenoic Acid (EPA) and Triglyceride Omega-3 are the strongest evidence signals for this outcome.
  • Dose fit1 of 2 dosed ingredients land in the studied range. Eicosapentaenoic Acid (EPA) at 2820 mg lands inside the studied 2000-4000 mg window.
  • Price / serving$1.73 per serving — high price tier for this outcome.
  • AvailabilityIn stock across major retailers; 99% availability confidence.
  • TrustLimited trust signals so far for this listing.

Trade-offs

Value for money trails the rest of this listTrust signals sit below the other picks

The numbers

78
88
76
34

2820 mgIn rangeinside the studied 2000-4000 mg window
2.8 gBelow rangebelow the studied 2000-4000 mg window
Compare top 3Product dataOpen at retailer

The rest of the ranking · DoseRank

Top 10 ranked products
#ProductPrice

Keep exploring

Related outcomes

Myocardial infarctionHeart attack or acute coronary event.StrokeCerebrovascular event causing neurologic injury.
Last updated Jun 12, 2026

DoseRank is not medical advice. Scores summarize publicly available product and study data to help you compare options; they are not a diagnosis or a treatment recommendation. If you are pregnant, breastfeeding, taking medication, or managing a health condition, consult a qualified clinician before starting any supplement. Retailer links may be affiliate links and DoseRank may earn a commission — rankings and placement are determined by the scoring model only, never by payment from a brand. Statements about supplements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Comparison preview

Compare the top 3, side by side

Sign-in to see all metrics

The top three for the current view — free to read, no account. Saving, exporting, alerts and the full filter set unlock once you sign in or build a personal report.

Metric
#1Metagenics, OmegaGenics®, Fish Oil EPA-DHA Liquid, Natural Lemon, 5 fl oz (150 ml)Metagenics · $1.73/serving
#2Nordic Naturals, Ultimate Omega® Xtra, Lemon, 8 fl oz (237 ml)Nordic Naturals · $1.32/serving
#3Nordic Naturals, ProOmega®-D Xtra, Great Lemon, 8 fl oz (237 ml)Nordic Naturals · $1.59/serving
Composite787774
Clinical888585
Dose fit766060
Value344036
Popularity676730
Key dosages & price · raw values
2820 mgHighest1950 mg1950 mg
Rating
Number of ratings
Price
Price per serving
Serving size
Trust

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