Reduce cachexia

What this outcome means

Cachexia is the involuntary loss of weight and muscle that comes with serious chronic illness, beyond simple dieting or low appetite. On DoseRank it maps to a defined health outcome built from human studies on body weight, lean muscle mass, and appetite measures – data sourced from open sources and specialized resources. DoseRank is not medical advice.

Who it's for

During cancerMuscle and weight slipping away during cancer or its treatment.

Chronic illnessHeart, kidney, or lung disease draining body reserves over time.

Frail and olderAging adults losing strength alongside a fading appetite.

Stack buildersAlready taking supplements such as HMB or Calories and want the dose right.

Evidence level

74Moderate-strong

Calories – has strong public evidence, and HMB adds supporting evidence. DoseRank looks at both evidence quality and formula fit. A DoseFit Score of 89 means this product's ingredient forms and doses are close to what was used in the studies behind this ranking - DoseRank weights each product ingredient.

Best ingredients

Calories leads this outcome, supported by HMB.

Dose matchedDoseFit 89

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: HMB 3 g vs 3-3 g; Below range: Calories 15 kcal vs 2000-4000 kcal.

Processed

8.5k

Available

8.5k

Ingredients

Brands

601

Coverage

100%

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

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Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.

Reduce cachexia

What this outcome means

Who it's for

During cancerMuscle and weight slipping away during cancer or its treatment.

Chronic illnessHeart, kidney, or lung disease draining body reserves over time.

Frail and olderAging adults losing strength alongside a fading appetite.

Stack buildersAlready taking supplements such as HMB or Calories and want the dose right.

Evidence level

74Moderate-strong

Best ingredients

Calories leads this outcome, supported by HMB.

Dose matchedDoseFit 89

Scores reward products dosed inside or above the studied range, not just the right ingredient. Examples: In range: HMB 3 g vs 3-3 g; Below range: Calories 15 kcal vs 2000-4000 kcal.

Processed

8.5k

Available

8.5k

Ingredients

Brands

601

Coverage

100%

Relevant ingredients

Which ingredient types matter for cachexiaOpen to see which ingredient types matter for cachexia

35 products across 1 ingredient types — open to filter the ranking.

Use types to filter ranked products

Amino Acids & Derivatives

35 products

The building blocks of protein, taken singly for targeted effects – leucine for muscle, theanine for calm. Free-form versions absorb fast on an empty stomach.

Typical:

Top decision cards

Best products for cachexia

Ranking by · Composite outcome score

Best overall — the composite outcome score.

Top pick · DoseRank

Why this ranks #1 for cachexia

Optimum Nutrition, HMB, 90 Capsules (1,000 mg per Capsule)

Optimum Nutrition$1.33 / serving4.4 · 1,129Available now

Why this ranks here

Evidence fitCalories leads the evidence here, backed by HMB.
Dose fit1 of 2 dosed ingredients land in the studied range. HMB at 3 g lands inside the studied 3-3 g window.
Price / serving$1.33 per serving — high price tier for this outcome.
AvailabilityIn stock across major retailers; 99% availability confidence.
TrustSolid trust signals from buyer ratings, with room to grow.

Trade-offs

Dose fit is the weak spot on this list

The numbers

3 gIn rangeinside the studied 3-3 g window

15 kcalBelow rangebelow the studied 2000-4000 kcal window

Compare top 3 Product data Open at retailer

The rest of the ranking · DoseRank

Top 10 ranked products