Everything DoseRank tracks on the vitamin b6 (pyridoxine) shelf — 5-Hydroxytryptophan (5-HTP) and Pyridoxal-5-Phosphate. The category itself is never ranked: 137 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing vitamin b6 (pyridoxine) supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 45 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
NauseaFeeling of sickness or urge to vomit.129 rankedStrong
Vitamin B6 statusBiochemical sufficiency of pyridoxine-related compounds.127 rankedStrong
Premenstrual symptom severityBurden of PMS-related mood or physical symptoms.127 rankedModerate-strong
HomocysteineAmino acid marker linked with vascular and methylation status.127 rankedStrong
Depressive symptomsLow mood, anhedonia, and related depressive features.121 rankedModerate-strong
Mean corpuscular volumeAverage red blood cell size.14 rankedStrong
Congenital anomalyStructural or functional birth defect.18 rankedStrong
VomitingForceful expulsion of stomach contents.9 rankedStrong
Vitamin B12 statusBiochemical sufficiency of cobalamin.21 rankedStrong
Gastroesophageal reflux or heartburnReflux symptoms causing burning or discomfort.24 rankedModerate-strong
Folate statusBiochemical sufficiency of folate.17 rankedStrong
Magnesium statusBiochemical sufficiency of magnesium.20 rankedStrong
Sleep latencyTime needed to fall asleep.10 rankedStrong
Sleep qualityOverall restfulness and perceived quality of sleep.32 rankedStrong
Migraine severityFrequency, duration, or intensity of migraine episodes.30 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best vitamin b6 (pyridoxine) supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 137 products against that goal's trials.