Everything DoseRank tracks on the tryptophan shelf — L-Tryptophan. The category itself is never ranked: 35 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing tryptophan supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 13 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
Sleep qualityOverall restfulness and perceived quality of sleep.34 rankedModerate-strong
Depressive symptomsLow mood, anhedonia, and related depressive features.34 rankedModerate-strong
NauseaFeeling of sickness or urge to vomit.34 rankedStrong
Vitamin B6 statusBiochemical sufficiency of pyridoxine-related compounds.5 rankedStrong
HomocysteineAmino acid marker linked with vascular and methylation status.5 rankedStrong
Premenstrual symptom severityBurden of PMS-related mood or physical symptoms.5 rankedModerate-strong
Pain intensitySeverity of pain regardless of body site.1 rankedStrong
Fat oxidationUse of fat as an energy source.1 rankedModerate-strong
AppetiteDesire to eat; may be clinically favorable or unfavorable depending on context.1 rankedModerate-strong
Niacin statusBiochemical sufficiency of vitamin B3.1 rankedStrong
ThermogenesisHeat production and metabolic energy expenditure.1 rankedStrong
Resting energy expenditureCalories burned at rest; marker of basal metabolism.1 rankedStrong
SatietySense of fullness after eating.1 rankedLimitedNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best tryptophan supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 35 products against that goal's trials.