Everything DoseRank tracks on the st. john's wort shelf — SAMe. The category itself is never ranked: 76 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing st. john's wort supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 45 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
CholestasisImpaired bile flow or bile obstruction.13 rankedStrong
Calmness or relaxationReduced tension and greater sense of calm.10 rankedStrong
Withdrawal symptomsSymptoms occurring after reduction or cessation of use.4 rankedLimited
Liver functionOverall biochemical or clinical hepatic performance.18 rankedModerate-strong
VertigoFalse sensation of spinning or motion.3 rankedModerate-strong
Tinnitus severityLoudness, distress, or impact of ringing in the ears.3 rankedLimited
Pregnancy rateFrequency of achieved pregnancies.1 rankedModerate-strong
Arrhythmia occurrenceAbnormal heart rhythm episodes.6 rankedLimited
Pain intensitySeverity of pain regardless of body site.9 rankedStrong
Visual acuityClarity or sharpness of vision.3 rankedModerate-strong
AppetiteDesire to eat; may be clinically favorable or unfavorable depending on context.10 rankedModerate-strong
Sleep qualityOverall restfulness and perceived quality of sleep.34 rankedModerate-strong
Anxiety symptomsWorry, tension, fear, or related anxiety manifestations.31 rankedStrong
Depressive symptomsLow mood, anhedonia, and related depressive features.37 rankedModerate-strong
Joint painPain arising from joints or periarticular tissues.29 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best st. john's wort supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 76 products against that goal's trials.