SAM-e Tosylate

Everything DoseRank tracks on the sam-e tosylate shelf — SAMe. The category itself is never ranked: 40 products get scored the moment you say what you want them to do.

Processed

40

Goals

10

Ingredients

1

Brands

11

Coverage

100%

Start with a goal, not a brand

What should sam-e tosylate supplements fix for you?

One goal at a time — every score below is computed against the goal you pick, nothing else.

Browsing sam-e tosylate supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 10 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.

Joint painPain arising from joints or periarticular tissues.40 rankedModerate-strong

Depressive symptomsLow mood, anhedonia, and related depressive features.40 rankedModerate-strong

Mean corpuscular volumeAverage red blood cell size.2 rankedStrong

Congenital anomalyStructural or functional birth defect.2 rankedStrong

Folate statusBiochemical sufficiency of folate.2 rankedStrong

Vitamin B12 statusBiochemical sufficiency of cobalamin.2 rankedStrong

HomocysteineAmino acid marker linked with vascular and methylation status.2 rankedStrong

Neuropathy symptomsPain, numbness, or dysfunction due to peripheral nerve problems.2 rankedStrong

Endothelial functionAbility of blood vessels to dilate and respond normally.2 rankedModerate-strong

FatiguePersistent tiredness, low stamina, or lack of energy.2 rankedModerate-strong

Nothing is ranked yet — the shelf stays locked until you pick a goal.

No goal, no ranking.

A “best sam-e tosylate supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 40 products against that goal's trials.

How to read the scores

What every metric means

Each score is 0–100. Higher is better for every metric below.

CompositeThe overall DoseRank score — a weighted blend of clinical strength, evidence, dose fit, trust and value.Higher is better

ClinicalHow strongly the formula's ingredients and doses match what clinical studies used for this outcome.Higher is better

EvidenceHow much published human research backs the formula's key ingredients for this outcome — both how many studies exist and how strong they are.Higher is better

ValueHow the price per serving compares with similar products for this outcome — 50 is the typical price, higher means better value for your money.Higher is better

TrustHow well customers rate this product, with extra weight given to ratings backed by a large number of reviews.Higher is better

PopularityHow strongly this product sells compared with the other ranked products for this outcome.Higher is better

This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →

Not sure which goal fits you?

Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.

Take 60-sec quiz

Get a personal report

A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.

Questions

Frequently asked

Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.