Everything DoseRank tracks on the sam-e shelf — SAMe. The category itself is never ranked: 57 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing sam-e supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 12 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
CholestasisImpaired bile flow or bile obstruction.57 rankedStrong
Liver functionOverall biochemical or clinical hepatic performance.57 rankedModerate-strong
Joint painPain arising from joints or periarticular tissues.57 rankedModerate-strong
Depressive symptomsLow mood, anhedonia, and related depressive features.57 rankedModerate-strong
Mean corpuscular volumeAverage red blood cell size.2 rankedStrong
Congenital anomalyStructural or functional birth defect.2 rankedStrong
Folate statusBiochemical sufficiency of folate.2 rankedStrong
Vitamin B12 statusBiochemical sufficiency of cobalamin.2 rankedStrong
HomocysteineAmino acid marker linked with vascular and methylation status.2 rankedStrong
Neuropathy symptomsPain, numbness, or dysfunction due to peripheral nerve problems.2 rankedStrong
Endothelial functionAbility of blood vessels to dilate and respond normally.2 rankedModerate-strong
FatiguePersistent tiredness, low stamina, or lack of energy.3 rankedModerate-strongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best sam-e supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 57 products against that goal's trials.