Everything DoseRank tracks on the primer shelf. The category itself is never ranked: 37 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing primer supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 45 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
Gamma-glutamyl transferase (GGT)Marker of cholestasis, alcohol exposure, or hepatic stress.1 rankedModerate-strong
Behavioral symptomsUndesired behavioral disturbances such as agitation or impulsivity.1 rankedLimited
Overall survivalLength of survival during follow-up; higher is better.3 rankedStrong
Ketone levelsCirculating ketone concentrations, relevant in fasting or ketogenic states.2 rankedStrong
Angina symptomsChest discomfort due to reduced cardiac blood flow.1 rankedModerate-strong
Aspartate aminotransferase (AST)Enzyme used to assess liver and muscle injury.3 rankedStrong
IrritabilityLow threshold for frustration or anger.2 rankedStrong
Joint stiffnessReduced ease of joint movement, especially after rest.6 rankedStrong
Skin elasticityAbility of skin to stretch and recoil.6 rankedStrong
Libido or sexual desireInterest in sexual activity.2 rankedModerate-strong
Omega-3 indexRed blood cell EPA+DHA content reflecting omega-3 status.4 rankedStrong
Arterial stiffnessReduced elasticity of arteries associated with cardiovascular risk.6 rankedStrong
Joint functionAbility of joints to move and support normal activity.7 rankedStrong
Sexual functionOverall sexual performance and satisfaction.2 rankedModerate-strong
Vascular functionOverall health and reactivity of the circulatory system.6 rankedModerate-strongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best primer supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 37 products against that goal's trials.