Everything DoseRank tracks on the pregnenolone shelf — Vitamin D3 (Cholecalciferol). The category itself is never ranked: 42 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing pregnenolone supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 45 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
All-cause mortalityDeath from any cause; lowest-level hard clinical outcome.28 rankedModerate-strong
Bone mineral densityMeasure of bone strength and mineralization.31 rankedStrong
Vitamin D statusBiochemical sufficiency of vitamin D.33 rankedStrong
Fall riskLikelihood of falling due to instability or weakness.28 rankedModerate-strong
Fracture riskLikelihood of bone fracture.28 rankedStrong
Ketone levelsCirculating ketone concentrations, relevant in fasting or ketogenic states.1 rankedStrong
Hair growth or densityIncrease or preservation of scalp or body hair.3 rankedLimited
Calcium statusAdequacy of calcium availability or stores.28 rankedStrong
Oxidative stress biomarkersLaboratory indicators of oxidative damage or redox imbalance.9 rankedModerate-strong
Depressive symptomsLow mood, anhedonia, and related depressive features.31 rankedStrong
Joint functionAbility of joints to move and support normal activity.4 rankedStrong
C-reactive proteinAcute-phase inflammatory marker.5 rankedStrong
Hepatic steatosisExcess fat accumulation in the liver.5 rankedModerate-strong
Joint stiffnessReduced ease of joint movement, especially after rest.2 rankedStrong
Antioxidant capacityMeasured ability to counter oxidative stress.13 rankedModerate-strongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best pregnenolone supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 42 products against that goal's trials.