Everything DoseRank tracks on the milk thistle shelf — Silybin Phytosome. The category itself is never ranked: 191 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing milk thistle supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 45 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
Aspartate aminotransferase (AST)Enzyme used to assess liver and muscle injury.169 rankedStrong
Lactation adequacySufficient breast milk production or breastfeeding success.110 rankedLimited
Hepatotoxicity or liver injuryClinically important harmful effect on the liver.84 rankedModerate-strong
Alanine aminotransferase (ALT)Liver enzyme used to assess hepatocellular injury.171 rankedStrong
Liver functionOverall biochemical or clinical hepatic performance.171 rankedStrong
Hepatic steatosisExcess fat accumulation in the liver.175 rankedModerate-strong
Gamma-glutamyl transferase (GGT)Marker of cholestasis, alcohol exposure, or hepatic stress.10 rankedModerate-strong
HbA1cAverage blood glucose marker over prior months.164 rankedModerate-strong
Fasting blood glucoseBlood glucose after fasting.174 rankedStrong
Antioxidant capacityMeasured ability to counter oxidative stress.176 rankedModerate-strong
Dyspepsia or indigestionUpper abdominal discomfort related to digestion.44 rankedStrong
Respiratory symptom burdenOverall severity of breathing-related symptoms.10 rankedStrong
LDL cholesterolLow-density lipoprotein cholesterol; lower is often preferred.62 rankedStrong
Inflammation biomarkersLaboratory measures of systemic or local inflammation.55 rankedStrong
OvulationOccurrence and quality of ovulatory cycles.12 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best milk thistle supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 191 products against that goal's trials.