Everything DoseRank tracks on the l-ergothioneine shelf — NMN. The category itself is never ranked: 12 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing l-ergothioneine supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 13 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
Energy or vitalitySubjective sense of energy, drive, or liveliness.3 rankedLimited
Inflammation biomarkersLaboratory measures of systemic or local inflammation.12 rankedStrong
Exercise toleranceAbility to continue activity without unacceptable symptoms.1 rankedStrong
Vascular functionOverall health and reactivity of the circulatory system.2 rankedStrong
Endothelial functionAbility of blood vessels to dilate and respond normally.4 rankedStrong
Antioxidant capacityMeasured ability to counter oxidative stress.7 rankedModerate-strong
Insulin sensitivityEfficiency of tissue response to insulin.4 rankedStrong
C-reactive proteinAcute-phase inflammatory marker.2 rankedModerate-strong
Sleep qualityOverall restfulness and perceived quality of sleep.3 rankedLimited
Blood pressureArterial pressure; direction of benefit depends on baseline status.4 rankedModerate-strong
MemoryAbility to encode, store, and retrieve information.2 rankedLimited
Cognitive functionOverall thinking ability including memory, attention, and processing.2 rankedLimited
Migraine severityFrequency, duration, or intensity of migraine episodes.1 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best l-ergothioneine supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 12 products against that goal's trials.