Everything DoseRank tracks on the circulatory support shelf — NMN and NAD+. The category itself is never ranked: 807 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
A category alone does not say what you want the product to do. The same category can lead on sleep for one shopper and stress for another, and the evidence behind each pick differs. Picking the medical outcome first lets DoseRank rank this category's products against that outcome's studies and doses.
No. Dose-fit rewards landing inside the range studied for the outcome — over-dosing (common with melatonin) or under-dosing both lower the score. The goal is the effective dose, not the biggest number.
The Value score compares a product's price per serving with clinically relevant products ranked for the same outcome. A score of 50 is the typical price; above 50 means better value than typical, while below 50 means the product costs more than typical. It is a 0–100 value signal, not a percentile.
Cost is only one input. A cheap pick can trail on the composite when it uses a weaker form, misses the studied dose, or carries a stock-risk flag — the composite also weighs evidence, dose fit and availability.
Retailer links may be affiliate links and DoseRank may earn a commission. Rankings and placement are determined by the scoring model only — never by payment from a brand.
No. DoseRank summarizes evidence to help you choose; it is not a substitute for a clinician, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.
Start with a goal, not a brand
Browsing circulatory support supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 45 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
Energy or vitalitySubjective sense of energy, drive, or liveliness.128 rankedLimited
Arterial stiffnessReduced elasticity of arteries associated with cardiovascular risk.266 rankedStrong
Niacin statusBiochemical sufficiency of vitamin B3.210 rankedStrong
Nitric oxide bioavailabilityAvailability of nitric oxide relevant to vascular function.131 rankedStrong
Power outputAbility to generate force rapidly.93 rankedStrong
Female fertilityAbility to conceive through female reproductive capacity.75 rankedModerate-strong
LDL cholesterolLow-density lipoprotein cholesterol; lower is often preferred.254 rankedStrong
Insulin sensitivityEfficiency of tissue response to insulin.214 rankedModerate-strong
HDL cholesterolHigh-density lipoprotein cholesterol; higher is often preferred.68 rankedStrong
Precancerous lesion progressionWorsening or advancement of premalignant lesions.85 rankedStrong
Endurance performanceAbility to maintain effort over a prolonged duration.122 rankedStrong
Aerobic capacity (VO2 max)Maximum oxygen utilization during exercise.104 rankedModerate-strong
Blood pressureArterial pressure; direction of benefit depends on baseline status.537 rankedStrong
Cognitive functionOverall thinking ability including memory, attention, and processing.288 rankedModerate-strong
FatiguePersistent tiredness, low stamina, or lack of energy.268 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best circulatory support supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 807 products against that goal's trials.