Everything DoseRank tracks on the akkermansia shelf — Lion's Mane. The category itself is never ranked: 22 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing akkermansia supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 36 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
Brain fogSubjective cognitive slowing or reduced mental clarity.2 rankedLimited
Insulin resistanceReduced response to insulin associated with metabolic disease.10 rankedStrong
Fasting blood glucoseBlood glucose after fasting.18 rankedStrong
AppetiteDesire to eat; may be clinically favorable or unfavorable depending on context.8 rankedModerate-strong
HbA1cAverage blood glucose marker over prior months.10 rankedStrong
Wrinkle severityDegree of visible skin wrinkling.2 rankedModerate-strong
Free testosteroneBiologically active unbound testosterone fraction.2 rankedLimited
Hepatic steatosisExcess fat accumulation in the liver.5 rankedModerate-strong
Intestinal permeabilityBarrier integrity and leakiness of the gut lining.3 rankedModerate-strong
TriglyceridesCirculating triglyceride concentration.10 rankedStrong
Atopic dermatitis symptomsItching, rash, and inflammation related to eczema.5 rankedModerate-strong
LDL cholesterolLow-density lipoprotein cholesterol; lower is often preferred.8 rankedStrong
Riboflavin statusBiochemical sufficiency of vitamin B2.3 rankedStrong
Fat oxidationUse of fat as an energy source.3 rankedModerate-strong
ConstipationInfrequent, difficult, or hard bowel movements.15 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best akkermansia supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 22 products against that goal's trials.