Everything DoseRank tracks on the 5-htp shelf — 5-Hydroxytryptophan (5-HTP) and Chromium Polynicotinate. The category itself is never ranked: 100 products get scored the moment you say what you want them to do.
How to read the scores
This legend covers the scores on this page — for data sources, scoring weights, and limits, read the full methodology →
Answer a few questions about your goals, habits, stack, and budget. Then, DoseRank will find the products that best match your needs based on your answers. It's free and only takes 60 seconds! No account is required.
A saved, shareable breakdown: your matched products, dose math, interaction flags to discuss with a clinician, and a price-tracked stack you can revisit.
Questions
Each product gets a composite score blending clinical strength, evidence, dose fit, trust and value — computed for the goal you picked, across this category's products. The #1 on the DoseRank tab has the highest composite; the other tabs re-rank the same products by Value, Trust, or Popularity. Placement is never paid.
Start with a goal, not a brand
Browsing 5-htp supplements without a goal makes no sense — different products do different jobs, and “best” flips depending on which job you're hiring for. These are the 44 health outcomes that matter for this category. Pick yours, and the full evidence-ranked shelf loads for that goal alone.
AppetiteDesire to eat; may be clinically favorable or unfavorable depending on context.96 rankedModerate-strong
Sleep qualityOverall restfulness and perceived quality of sleep.99 rankedModerate-strong
Anxiety symptomsWorry, tension, fear, or related anxiety manifestations.96 rankedStrong
SatietySense of fullness after eating.96 rankedModerate-strong
Vitamin B6 statusBiochemical sufficiency of pyridoxine-related compounds.43 rankedStrong
Migraine severityFrequency, duration, or intensity of migraine episodes.96 rankedModerate-strong
Depressive symptomsLow mood, anhedonia, and related depressive features.96 rankedModerate-strong
HomocysteineAmino acid marker linked with vascular and methylation status.43 rankedStrong
Calmness or relaxationReduced tension and greater sense of calm.9 rankedStrong
Sleep latencyTime needed to fall asleep.12 rankedStrong
NauseaFeeling of sickness or urge to vomit.96 rankedStrong
Attention and concentrationAbility to sustain and direct focus.9 rankedModerate-strong
Insomnia severityDegree of difficulty initiating or maintaining sleep.4 rankedStrong
Vitamin C statusBiochemical sufficiency of ascorbic acid.12 rankedStrong
Urinary frequencyNeeding to urinate more often than normal.2 rankedStrongNothing is ranked yet — the shelf stays locked until you pick a goal.
No goal, no ranking.
A “best 5-htp supplement” list without a goal would be marketing, not evidence. Pick what you want to improve and DoseRank scores all 100 products against that goal's trials.